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KMID : 1143120180080040037
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Asia Pacific Allergy
2018 Volume.8 No. 4 p.37 ~ p.37
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A pediatric case of anaphylactic shock induced by tipepidine hibenzate (Asverin)
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Takai Hirotake
Kato Izumi
Mitsunaga Kanako
Hara Mayumi
Kodama Takahiro
Kanazawa Masaki
Terai Masaru
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Abstract
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Tipepidine hibenzate (Asverin) is commonly used as an antitussive drug for acute and chronic cough in various age groups and is generally safe and well-tolerated. However, we experienced a case of tipepidine hibenzate-induced anaphylactic shock in a 1-year-old boy. After ingesting cold medication including tipepidine hibenzate, the patient presented with generalized erythema and urticaria, swollen face, coughing, wheezing and vomiting, together with hypotension and a decreased level of consciousness. To identify the culprit drug, we performed skin prick tests (SPTs) and oral drug provocation tests (DPTs). SPTs revealed a negative reaction for all drugs, but DPTs caused a positive reaction only for a full therapeutic dose of tipepidine hibenzate. Physicians need to consider tipepidine hibezate as a culprit drug when anaphylaxis occurs after taking anticough or common cold medication.
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KEYWORD
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Anaphylaxis, Anaphylactic shock, Drug allergy, Asverin, Tipepidine hibenzate, Child
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